tag:blogger.com,1999:blog-5782851813932033648.post826530352553506624..comments2023-04-04T02:46:51.633-07:00Comments on My Journey with Multiple Sclerosis: LaquinimodKimberlyhttp://www.blogger.com/profile/07890715800273372678noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-5782851813932033648.post-25849803312740824902010-12-10T11:45:01.477-08:002010-12-10T11:45:01.477-08:00The mechanism of action would be most interesting ...The mechanism of action would be most interesting - is it in fact similar to Fingolimod, (a sphingosine 1-phosphate receptor (S1PR)) modulator, that acts by holding the white blood cell at bay. The chemical structure of Laquinimod is quite different. It is interesting to note the addition of the Cl atom and the N-ethyl to Laquinimod that distinguishes it from its failed quinoline derivative predecessor (Roquinimex (Linomide) that has the identical structure but without the Chlorine atom and the N-ethyl substituted for the N-methyl. Of course Teva will have to take a very close look whether there is a statistical increase in melanomas and cardiac implications in the safety trials. <br /><br />J D Block D Pharm<br />Locum InternationalJ DBlockhttp://www.iagim.orgnoreply@blogger.comtag:blogger.com,1999:blog-5782851813932033648.post-59272721439655092912010-04-16T05:54:26.796-07:002010-04-16T05:54:26.796-07:00This would be sooo wonderful! I want to toss the ...This would be sooo wonderful! I want to toss the needles out the window!<br /><br />Have a great day!<br />Erin~Erin~https://www.blogger.com/profile/16710412631383800874noreply@blogger.com